Characteristics of brief resolved unexplained events at a pediatric medical care center in Venezuela

Authors

DOI:

https://doi.org/10.37711/

Keywords:

brief resolved unexplained event, recurrence, diagnosis, hospitalization, gastroesophageal reflux

Abstract

Objective. To describe the characteristics of brief resolved unexplained events (BRUE) at a pediatric medical care center in Venezuela between January 2021 and October 2025. Methods. An observational study with descriptive analysis of 178 patients meeting BRUE criteria, selected through consecutive non-probability sampling, who presented to the emergency department or outpatient clinic. Pearson’s chi-square test and the Mann–Whitney U test were used. Results. 9% of patients developed an underlying disease. Recurrence occurred in 33.1% of cases, and 48.9% were classified as high risk. The most frequently diagnosed underlying disease was gastroesophageal reflux. 5.1% were hospitalized, and additional diagnostic tests were performed in 57.9% of cases. Factors associated with recurrence included altered level of consciousness, high-risk BRUE, abnormal perinatal history, and subsequent diagnosis of an underlying disease. Factors associated with an underlying disease were age under 60 days, high-risk BRUE, recurrence of the event, prematurity, and frequent regurgitation. Conclusions. BRUE accounted for 1.3% of emergency visits; 9% of patients developed an underlying disease, one-third experienced recurrence, and half were classified as high risk. 5.1% were hospitalized, and no deaths were recorded.

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References

1. Sahewalla R, Gupta D, Kamat D. Apparent life-threatening events: an overview. Clin Pediatr. (Phila) [Internet]. 2016 [Consultado el 9 de junio de 2025];55(1):5-9. https://doi.org/10.1177/0009922815591890

2. Kondamudi NP, Virji M. Breve informe de un suceso inexplicable resuelto. [Internet]. Treasure Island: StatPearls Publishing; enero de 2025. [Consultado el 9 de junio de 2025]. https://www.ncbi.nlm.nih.gov/books/NBK441897/

3. Zenteno-Araos D, Díaz-Silva J, Brockmann-Veloso P. Aplicación de una nueva terminología “BRUE: Eventos breves, resueltos e inexplicados”. Definiciones y recomendaciones. Revista chilena de pediatría [Internet]. 2020 [Consultado el 9 de junio de 2025];91(3):424-431. https://doi.org/10.32641/rchped.v91i3.920

4. Tieder J, Sullivan E, Stephans A, Hall M, DeLaroche A, Wilkins V, et al. Risk Factors and Outcomes After a Brief Resolved Unexplained Event: A Multicenter Study. Pediatrics [Internet]. 2021 [Consultado el 9 de junio de 2025];148(1):e2020036095. https://doi.org/10.1542/peds.2020-036095

5. Bochner R, Tieder JS, Sullivan E, Hall M, Stephans A, Mittal MK, et al. Explanatory Diagnoses Following Hospitalization for a Brief Resolved Unexplained Event. Pediatrics [Internet]. 2021 [Consultado el 9 de junio de 2025];148(5):e2021052673. https://doi.org/10.1542/peds.2021-052673

6. Nama N, DeLaroche A, Bonkowsky J.L, Gremse D, Tieder J.S. Brief Resolved Unexplained Event: Evidence-Based and Family-Centered Management. Pediatr Rev. [Internet]. 2024 [Consultado el 1 de febrero de 2025];45(10):560-572. https://doi.org/10.1542/pir.2024-006351

7. Tieder J, Bonkowsky J, Etzel R, Franklin W, Gremse D, Herman B, et al. Brief Resolved Unexplained Events (Formerly Apparent Life-Threatening Events) and Evaluation of Lower-Risk Infants. Pediatrics [Internet]. 2016 [Consultado el 13 de junio de 2025];137(5):e20160590. https://doi.org/10.1542/peds.2016-0590

8. Nama N, Shen Y, Bone JN, Lee Z, Picco K, Jin F, et al. External Validation of Brief Resolved Unexplained Events Prediction Rules for Serious Underlying Diagnosis. JAMA Pediatr. [Internet]. 2025 [Consultado el 13 de junio de 2025];179(2):188-196. https://doi.org/10.1001/jamapediatrics.2024.4399

9. McConnochie K. Bronchiolitis. What´s in the name?. Am J Dis Child. [Internet]. 1983 [Consultado el 13 de junio de 2025];173:3-11. https://doi.org/10.1001/archpedi.1983.02140270007003

10. CSTE. Revision to the case definition for national pertussis surveillance. CSTE position statement 19-ID-08 [Internet]. Atlanta: CSTE; 2019 [Consultado el 11 de junio de 2025]. Disponible en: https://cdn.ymaws.com/www.cste.org/resource/resmgr/2019ps/final/19-ID-08_Pertussis_final_7.3.pdf

11. Hyman PE, Milla PJ, Benninga MA, Davidson GP, Fleiser DF, Taminiau J. Childhood functional gastrointestinal disorders: neonato/toddler. Gastroenterology [Internet]. 2006 [Consultado el 11 de junio de 2025];130:1519-1526. https://doi.org/10.1053/j.gastro.2005.11.065

12. Correa C, Osorio K, Riffo C, Luchinni V. Pacientes con diagnóstico de "BRUE" atendidos en hospital pediátrico chileno. Aplicando nueva terminología. Rev. chil. psiquiatr. neurol. infanc. Adolesc. [Internet]. 2021 [Consultado el 11 de junio de 2025];32(2):22-37. https://docs.bvsalud.org/biblioref/2023/01/1411799/rev_sopnia-2021-2-22-37.pdf

13. Denis M, Brulé C, Lauzier B, Brossier D, Porcheret F. Brief resolved unexplained event: Severity-associated factors at admission in the pediatric emergency ward. Arch Pediatr. [Internet]. 2023 [Consultado el 11 de junio de 2025];30(6):389-395. https://doi.org/10.1016/j.arcped.2023.05.005

14. Nama N, Lee Z, Picco K, Jin F, Bone J, Quet J, et al. Identifying serious underlying diagnoses among patients with brief resolved unexplained events (BRUEs): a Canadian cohort study. BMJ Paediatrics Open [Internet]. 2024 [Consultado el 17 de marzo de 2025];8:e002525. https://doi.org/10.1136/bmjpo-2024-002525

15. DeLaroche AM, Haddad R, Farooqi A, Sapién RE, Tieder JS. Outcome prediction of higher-risk brief resolved unexplained events. Hosp Pediatr. [Internet]. 2020 [Consultado el 22 de febrero de 2025];10(4):303-310. https://doi.org/10.1542/hpeds.2019-0195

16. Mittal MK, Tieder JS, Westphal K, et al. Diagnostic testing for evaluation of brief resolved unexplained events. Acad Emerg Med. [Internet]. 2023 [Consultado el 29 de enero de 2025];30:662-670. https://doi.org/10.1111/acem.14666

17. Brand DA, Fazzari MJ. Risk of death in infants who have experienced a brief resolved unexplained event: a meta-analysis. J Pediatr. [Internet]. 2018 [Consultado el 15 de febrero de 2025];197:63-67. https://doi.org/10.1016/j.jpeds.2017.12.028

18. Nama N, Hall M, Neuman M, Sullivan E, Bochner R, De Laroche A, et al. Brief Resolved Unexplained Event Research and Quality Improvement Network. Risk prediction after a brief resolved unexplained event. Hosp Pediatr. [Internet]. 2022 [Consultado el 30 de enero de 2025];12:772-785. https://doi.org/10.1542/hpeds.2022-006637

19. Merritt JL 2nd, Quinonez RA, Bonkowsky JL, Franklin WH, Gremse DA, Herman BE, et al. A Framework for Evaluation of the Higher-Risk Infant After a Brief Resolved Unexplained Event. Pediatrics [Internet]. 2019 [Consultado el 9 de enero de 2025];144(2):e20184101. http://dx.doi.org/10.1542/peds.2018-4101

20. Doswell A, Anderst J, Tieder JS, Herman BE, Hall M, Wilkins V, et al. Brief Resolved Unexplained Event Research and Quality Improvement Network. Diagnostic testing for and detection of physical abuse in infants with brief resolved unexplained events. Child Abuse Negl. [Internet]. 2023 [Consultado el 9 de febrero de 2025];135:105952. https://doi.org/10.1016/j.chiabu.2022.105952

21. Krmpotic K. A Clinical Approach to Altered Level of Consciousness in the Pediatric Patient. Austin Pediatr. [Internet]. 2016 [Consultado el 13 de enero de 2025];3(5): 1046. https://austinpublishinggroup.com/pediatrics/fulltext/ajp-v3-id1046.pdf

22. Ramgopal S, Colgan JY, Roland D, Pitetti RD, Katsogridakis Y. Brief resolved unexplained events: a new diagnosis, with implications for evaluation and management. Eur J Pediatr. [Internet]. 2022 [Consultado el 3 de enero de 2025];181(2):463-70. https://doi.org/10.1007/s00431-021-04234-5

23. McFarlin A. What to Do when Babies Turn Blue: Beyond the Basic Brief Resolved Unexplained Event. Emerg Med Clin North Am. [Internet]. 2018 [Consultado el 21 de enero de 2025];36:335-47. https://doi.org/10.1016/j.emc.2017.12.001

24. Reynoso V, Ursino F, Cohen J, Orsi M. La impedanciometría multicanal con pHmetría de 24 h: una herramienta útil para estudiar lactantes con eventos de aparente amenaza a la vida. Acta Gastroenterol Latinoam. [Internet]. 2021 [Consultado el 4 de febrero de 2025];51(1):52-56. https://doi.org/10.52787/zfer2678

25. Colombo M, Katz ES, Bosco A, Melzi ML, Nosetti L. Brief resolved unexplained events: Retrospective validation of diagnostic criteria and risk stratification. Pediatr Pulmonol. [Internet]. 2019 [Consultado el 17 de enero de 2025];54:61-5. https://doi.org/10.1002/ppul.24195

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Published

2025-10-13

How to Cite

1.
Naveda Romero O, Balza Tovar SV, Lagos Rodríguez TY, Yépez Y, Moiz R, Linares Cárdenas F, et al. Characteristics of brief resolved unexplained events at a pediatric medical care center in Venezuela. Rev Peru Cienc Salud [Internet]. 2025 Oct. 13 [cited 2026 Jan. 1];7(4). Available from: https://revistas.udh.edu.pe/RPCS/article/view/947

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