Epidemiological, laboratory and treatment characteristics in hemodialysis patients in a high altitude population

Authors

DOI:

https://doi.org/10.37711/rpcs.2022.4.2.370

Keywords:

anemia, renal dialysis, altitude, Peru

Abstract

Objective. To describe the prevalence of anemia among patients undergoing chronic hemodialysis treatment in an altitude population (3200 m a.s.l.) in the Department of Junín (Peru). Methods. Observational, retrospective study. Data were taken from the National Dialysis Registry (RENDES, 2021) in the Department of Junín (Peru) and from the medical records of hemodialysis patients of the EsSalud Social Security in the year 2021. The sample population consisted of all patients who constituted the Chronic Hemodialysis Program of the Junín Region. Descriptive data were analyzed in Stata, version 17.0. Results. The prevalence of anemia was 3.9%. Only 5 patients had anemia associated with chronic kidney disease (CKD) (3.9%). Data were collected from 128 patients. 64.8% (n = 83) were male. The main cause of CKD was arterial hypertension (AHT) (37.5%), then type 2 diabetes mellitus (24.2%). The mean hemoglobin was 12.8 ± 2.38 g/dL. Mean mean corpuscular volume (MCV) was 95.42 ± 4.9 fl, mean corpuscular hemoglobin (MCH) 32.13± 1.9 pc, and mean corpuscular hemoglobin concentration (MCHC) mean was 33 ± 1.15 g/dL. The average serum iron level was 100 micromol/L and the average ferritin level was 1300 ng/ml. Patients used on average 23000 IU of erythropoietin (EPO) monthly, 400 mg of iron monthly and 4 mg of hydroxocobalamin monthly. Conclusions. Anemia rates in patients with chronic hemodialysis treatment in Huancayo, Junín, in a high altitude city, are low (3.9%).

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References

Gaitonde DY, Cook DL, Rivera IM. Chronic Kidney Disease: Detection and Evaluation. Am Fam Physician. 2017;96(12):776-783.

Centers for Disease Control and Prevention. Chronic kidney disease (CKD) surveillance system. [Consultado 2017 Ener 20]. Disponible en: https://nccd.cdc.gov/CKD/data.aspx

Verhulst D. Caractéristiques et épidémiologie de la maladie rénale chronique. Soins [Internet]. 2018 [Consultado 2022 Mar 20]; 63(826): 14-16. doi: 10.1016/j.soin.2018.04.004

Lv, Ji-Cheng, and Lu-Xia Zhang. Prevalence and Disease Burden of Chronic Kidney Disease. En: Bi-Cheng Liu et al. Renal Fibrosis: Mechanisms and Therapies, vol. 1165, Springer Singapore [Internet]. 2019 [Consultado 2022 Mar 21]. pp. 3-15, doi: 10.1007/978-981-13-8871-2_1

Herrera-Añazco P, Pacheco-Mendoza J, Taype-Rondan A. La enfermedad renal crónica en el Perú. Una revisión narrativa de los artículos científicos publicados. Acta Médica Peruana [Internet]. 2016 [Consultado 2022 Mar 21]; 33(2): 130–37. Disponible en: http://www.scielo.org.pe/pdf/amp/v33n2/a07v33n2.pdf

Herrera-Añazco P, Taype-Rondan A, Lazo-Porras M, Alberto Quintanilla E, Ortiz-Soriano VM, Hernández AV. Prevalence of chronic kidney disease in Peruvian primary care setting. BMC Nephrol. [Internet]. 2017 [Consultado 2022 Mar 22]; 18(1): 246. doi: 10.1186/s12882-017-0655-

Ammirati AL. Chronic Kidney Disease Rev Assoc Med Bras [Internet]. 2020 [Consultado 2022 Mar 21]; 66(Suppl 1): s03-s09. doi: 10.1590/1806-9282.66. S1.3

Gafter-Gvili A, Schechter A, Rozen-Zvi B. (2019). Iron Deficiency Anemia in Chronic Kidney Disease. Acta haematologica [Internet]. 2019 [Consultado 2022 Mar 21]; 142(1): 44–50. https://doi.org/10.1159/000496492

Cases A, Egocheaga MI, Tranche S, Pallarés V, Ojeda R, Górriz JL, et al. Anemia en la enfermedad renal crónica: protocolo de estudio, manejo y derivación a Nefrología. Atención primaria [Internet]. 2018 [Consultado 2022 Mar 25]; 50(1), 60–64. https://doi.org/10.1016/j.aprim.2017.09.007

Gafter-Gvili A, Schechter A, Rozen-Zvi B. Iron Deficiency Anemia in Chronic Kidney Disease. Acta Haematol. 2019;142(1):44-50. doi:10.1159/000496492

Berns JS, Elzein H, Lynn RI, Fishbane S, Meisels IS, Deoreo PB: Hemoglobin variability in epoetin-treated hemodialysis patients. Kidney Int .2003; 64: 1514 –1521.

Brookhart MA, Schneeweiss S, Avorn J, Bradbury BD, Rothman KJFischer M, et al. The effect of altitude on dosing and response to erythropoietin in ESRD. J Am Soc Nephrol. [Internet]. 2008 jul [Consultado 2022 Mar 25]; 19(7): 1389-95. doi: 10.1681/ASN.2007111181

Perú. Instituto Nacional de Estadística e Informática. Estimaciones y Proyecciones de Población por Departamento Provincia y Distrito 2020. Lima: INEI; 2020. Disponible en: https://www.inei.gob.pe/media/MenuRecursivo/publicaciones_digitales/Est/Lib1715/Libro.pdf

Atamari-Anahui N, Ccorahua-Rios MS, Condori-Huaraka M, Huamanvilca-Yepez Y, Amaya E, Herrera-Añazco P. Epidemiology of chronic kidney disease in Peru and its relation to social determinants of health. International Health [Internet]. 2020 [Consultado 2022 Mar 26]; 12(4): 264-271. https://doi.org/10.1093/inthealth/ihz071

Roy CN, Snyder PJ, Stephens-Shields AJ, Artz AS, Bhasin S, Cohen, HJ, et al. Association of Testosterone Levels with Anemia in Older Men: A Controlled Clinical Trial. JAMA internal medicine [Internet]. 2017 [Consultado 2022 Mar 26]; 177(4), 480–490. https://doi.org/10.1001/jamainternmed.2016.9540

Hinostroza M. Insuficiencia renal crónica terminal (IRCT) en hemodiálisis en el hospital Nacional Ramiro Prialé Prialé de Huancayo 2011-2015 [Internet] Huancayo: Universidad Nacional del Centro del Perú; 2026 [Consultado Año Mes Día; ej.: 2022 Ene 27]. Disponible en: http://repositorio.uncp.edu.pe/handle/20.500.12894/444

Meneses V, León C, Huapaya J, Cieza J. Sobrevida en hemodiálisis según el período de ingreso de pacientes entre 1982 y 2007 en Lima, Perú. Rev Med Hered. 2011; 22(4): 157-61.

Castillo O. Resistencia a la insulina y altura. Anales de la Facultad de Medicina [Internet]. 2015 [Consultado 2022 Mar 28]; 76(2), 181-186. https://dx.doi.org/dx.doi.org/10.15381/anales.v76i2.11145

Rutte CA. Contribución al aspecto clínico y epidemiológico de la diabetes mellitus [Tesis de bachiller]. Lima: Universidad Nacional Mayor de San Marcos; 1966.

Solís J, Guerra-García R. Prevalencia de diabetes mellitus en hospitalizados de las grandes alturas. Arch Biol Andina. 1979; 9: 21.

Seclén S, Leey J, Villena A, Herrera B, Menacho J, Carrasco A, et al. Prevalencia de obesidad, diabetes, hipertensión arterial e hipercolesterolemia como factores de riesgo coronario y cerebrovascular en población adulta de la costa, sierra y selva del Perú. Acta Médica Peruana. 1999; 16: 8-12.

Hurtado A, Palacios AM, Figueroa J, Gonzales J, Kaluguina de Yrigoin A, Lopera MT. Niveles de hemoglobina en pacientes en hemodiálisis a nivel del mar y a mayor altitud, y su relación con la calidad de vida. Rev Soc Perú Med Interna [Internet]. 2013 [2022 Mar 28]; 26(4). Disponible en: https://sisbib.unmsm.edu.pe/BVRevistas/spmi/v26n4/pdf/a05v26n4.pdf

Duran MF, Prado FA. Nivel óptimo de hemoglobina en pacientes con enfermedad renal crónica en ciudades de altura [Internet]. Cuenca: Universidad del Azuay; 2013 [Consultado 2022 Mar 28]. Disponible en: http://dspace.uazuay.edu.ec/bitstream/datos/2776/1/09845.p

Collister D, Rigatto C, Tangri N. Anemia management in chronic kidney disease and dialysis: a narrative review. Curr Opin Nephrol Hypertens. [Internet]. 2017 May [Consultado 2022 Mar 28]; 26(3): 214-218. doi: 10.1097/MNH.0000000000000317.

Haase VH. Regulation of erythropoiesis by hypoxia-inducible factors. Blood Rev. [Internet]. 2013 [2022 Mar 28]; 27(1): 41-53. doi: 10.1016/j.blre.2012.12.003

Santos EJF, Dias RSC, Lima JFB, Salgado Filho N, Miranda Dos Santos A. Erythropoietin Resistance in Patients with Chronic Kidney Disease: Current Perspectives. Int J Nephrol Renovasc Dis. [Internet]. 2020 oct 8 [2022 Mar 28]; 13: 231-237. doi:10.2147/IJNRD.S239151

Published

2022-06-13

How to Cite

1.
Arellán Bravo LJ, León Gonzales RF, Egoavil Izarra M, Poma Via Y Rada A, Mendoza Cairampoma DE. Epidemiological, laboratory and treatment characteristics in hemodialysis patients in a high altitude population. revista de salud udh [Internet]. 2022Jun.13 [cited 2024Jul.3];4(2):92-7. Available from: http://revistas.udh.edu.pe/index.php/RPCS/article/view/370e