Theoretical considerations of hydrogel therapy for periodontal tissue regeneration

Authors

DOI:

https://doi.org/10.37711/rpcs.2024.6.2.448

Keywords:

hydrogel, periodontal tissue regeneration, periodontitis, scaffold material, tissue engineering

Abstract

The removal of alveolar bone and periodontal ligament due to periodontal disease often
requires a surgical approach to reshape the biological structure and functions of the
periodontium. Hydrogel, a functional polymeric material, has emerged as a promising technology for periodontal disease therapies. It has the versatility to mimic the extracellular matrix and provide suitable binding sites and growth environments for periodontal cells, with high biocompatibility, water retention, and slow release. A review of the past 5 years of literature has been conducted, summarizing the main components of hydrogel in periodontal tissue regeneration.

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References

Wang H, Chang X, Ma Q, Sun B, Li H, Zhou J, et al. Bioinspired drug-delivery system emulating the natural bone healing cascade for diabetic periodontal bone regeneration. Bioact Mater [Internet]. Sep 14 [Consultado el 13 de mayo de 2023];21:324-339. doi: 10.1016/j.bioactmat.2022.08.029

Li M, Lv J, Yang Y, Cheng G, Guo S, Liu C, et al. Advances of Hydrogel Therapy in Periodontal Regeneration-A Materials Perspective Review. Gels. [Internet]. 2022 Sep 30 [Consultado el 13 de mayo de 2023];8(10):624. doi: 10.3390/gels8100624

Goto R, Nishida E, Kobayashi S, Aino M, Ohno T, Iwamura Y, et al. Gelatin Methacryloyl-Riboflavin (GelMA-RF) Hydrogels for Bone Regeneration. Int J Mol Sci. [Internet]. 2021 Feb 6 [Consultado el 13 de mayo de 2023];22(4):1635. doi: 10.3390/ijms22041635

Zhan H, Lowik DW. A hybrid peptide amphiphile fiber PEG hydrogel matrix for 3D cell culture. Adv.Funct.Mater. [Internet]. 2019 [Consultado el 17 de julio de 2023];29(16):1808505. doi: https://onlinelibrary.wiley.com/doi/10.1002/adfm.201808505

Zhang Y, Jiang R, Lei L, Yang Y, Hu T. Drug delivery systems for oral disease applications. J Appl Oral Sci. [Internet]. 2022 Mar 9 [Consultado el 17 de julio de 2023];30:e20210349. doi: 10.1590/1678-7757-2021-0349

Yuan W, Wang H, Fang C, Yang Y, Xia X, Yang B, et al. Microscopic local stiffening in a supramolecular hydrogel network expedites stem cell mechanosensing in 3D and bone regeneration. Mater. Horiz. [Internet]. 2021 [Consultado el 17 de julio de 2023];8(6):1722–1734. Disponible en: https://pubs.rsc.org/r/content/articlelanding/2021/MH/D1MH00244A

Yu T, Zhang L, Dou X, Bai R, Wang H, Deng J, et al. Mechanically Robust Hydrogels Facilitating Bone Regeneration through Epigenetic Modulation. Adv Sci (Weinh). [Internet]. 2022 Nov [Consultado el 17 de julio de 2023];9(32):e2203734. doi: 10.1002/advs.202203734

Rajeshwari HR, Dhamecha D, Jagwani S, Rao M, Jadhav K, Shaikh S, et al. Local drug delivery systems in the management of periodontitis: a scientifc review. J Control Release, [Internet]. 2019 [Consultado el 17 de julio de 2023];307:393- 409. doi: 10.1016/j.jconrel.2019.06.038

Praveen P, Suzuki S, Carson CF, Saunders M, Clode PL, Myers M, et al. Poly(2-hydroxyethyl methacrylate) sponges doped with Ag nanoparticles as antibacterial agents. ACS Applied Nano Materials. [Internet]. 2020 28 February [Consultado el 24 de agosto de 2023];3(2):1630-1639. doi: 10.1021/acsanm.9b02384

Karade VC, Patil RB, Parit SB, Kim JH, Chougale AD, Dawkar VV. Insights into shape-based silver nanoparticles: a weapon to cope with pathogenic attacks. ACS Sustainable Chem Eng [Internet]. 2021 [Consultado el 24 de agosto de 2023];9(37):12476-12507. doi: 10.1021/acssuschemeng.1c03797

Ye S, Wei B, Zeng L. Advances on Hydrogels for Oral Science Research. Gels. [Internet]. 2022 May 15 [Consultado el 24 de agosto de 2023];8(5):302. doi: 10.3390/gels8050302

Kreller T, Distler T, Heid S, Gerth S, Detsch R, Boccaccini AR. Physico-chemical modification of gelatine for the improvement of 3D printability of oxidized alginate-gelatine hydrogels towards cartilage tissue engineering. Mater. Des. [Internet]. 2021 [Consultado el 24 de agosto de 2023];208:109877. doi: https://doi.org/10.1016/j.matdes.2021.109877

Meena LK, Raval P, Kedaria D, Vasita R. Study of locust bean gum reinforced cyst-chitosan and oxidized dextran based semi-IPN cryogel dressing for hemostatic application. Bioact Mater. [Internet]. 2017 Dec 8 [Consultado el 10 de setiembre de 2023];3(3):370-384. doi: 10.1016/j.bioactmat.2017.11.005

Zhang Y, Dou X, Zhang L, Wang H, Zhang T, Bai R, et al. Facile fabrication of a biocompatible composite gel with sustained release of aspirin for bone regeneration. Bioact Mater. [Internet]. 2021 Oct 5 [Consultado el 10 de setiembre de 2023];11:130-139. doi: 10.1016/j.bioactmat.2021.09.033

Eshwar S, Konuganti K, Manvi S, Bharadwaj AN, Sajjan S, Boregowda SS, et al. Evaluation of Osteogenic Potential of Fucoidan Containing Chitosan Hydrogel in the Treatment of Periodontal Intra-Bony Defects-A Randomized Clinical Trial. Gels. [Internet]. 2023 Jul 13 [Consultado el 10 de setiembre de 2023];9(7):573. doi: 10.3390/gels9070573

Shafei S, Khanmohammadi M, Heidari R, Ghanbari H, Taghdiri Nooshabadi V, Farzamfar S, et al. Exosome loaded alginate hydrogel promotes tissue regeneration in full-thickness skin wounds: An in vivo study. J Biomed Mater Res A. [Internet]. 2020 Mar [Consultado el 10 de setiembre de 2023];108(3):545-556. doi: 10.1002/jbm.a.36835

Iskandar L, Rojo L, Di Silvio L, Deb S. The effect of chelation of sodium alginate with osteogenic ions, calcium, zinc, and strontium. J Biomater Appl. [Internet]. 2019 Oct [Consultado el 10 de setiembre de 2023];34(4):573-584. doi: 10.1177/0885328219861904

Lueckgen A, Garske DS, Ellinghaus A, Desai RM, Stafford AG, Mooney DJ, et al. Hydrolytically-degradable click-crosslinked alginate hydrogels. Biomaterials. [Internet]. 2018 Oct [Consultado el 10 de setiembre de 2023];181:189-198. doi: 10.1016/j.biomaterials.2018.07.031

Chen M, Li L, Wang Z, Li P, Feng F, Zheng X. High molecular weight hyaluronic acid regulates P. gingivalis-induced inflammation and migration in human gingival fibroblasts via MAPK and NF-kB signaling pathway. Arch Oral Biol. [Internet]. 2019 Feb [Consultado el 10 de setiembre de 2023];98:75-80. doi: 10.1016/j.archoralbio.2018.10.027

Rosaming P, Jirayupapong J, Thamnium S, Win YY, Limprasutr V, Rodsiri R, et al. Interpenetrating Low-Molecular Weight Hyaluronic Acid in Hyaluronic Acid-Based In Situ Hydrogel Scaffold for Periodontal and Oral Wound Applications. Polymers (Basel). [Internet]. 2022 Nov 17 [Consultado el 10 de setiembre de 2023];14(22):4986. doi:10.3390/polym14224986

Guo S, He L, Yang R, Chen B, Xie X, Jiang B, et al. Enhanced effects of electrospun collagen-chitosan nanofiber membranes on guided bone regeneration. J Biomater Sci Polym Ed. [Internet]. 2020 Feb [Consultado el 10 de setiembre de 2023]; 31(2):155-168. doi: 10.1080/09205063.2019.1680927

Janjic K, Agis H, Moritz A, Rausch-Fan X, Andrukhov O. Effects of collagen membranes and bone substitute differ in periodontal ligament cell microtissues and monolayers. J Periodontol. [Internet]. 2022 May [Consultado el 12 de octubre de 2023];93(5):697-708. doi: 10.1002/JPER.21-0225

Panczyszyn E, Jasko M, Milek O, Niedziela M, Mecik-Kronenberg T, Hoang-Bujnowicz A, et al. Gellan gum hydrogels cross-linked with carbodiimide stimulates vacuolation of human tooth-derived stem cells in vitro. Toxicol In Vitro. [Internet]. 2021 Jun [Consultado el 12 de octubre de 2023];73:105111. doi: 10.1016/j.tiv.2021.105111

Oliveira IM, Gonçalves C, Shin ME, Lee S, Reis RL, Khang G, et al. Anti-Inflammatory Properties of Injectable Betamethasone-Loaded Tyramine-Modifed Gellan Gum/Silk Fibroin Hydrogels. Biomolecules. [Internet]. 2020 Oct 17 [Consultado el 12 de octubre de 2023];10(10):1456. doi: 10.3390/biom10101456

Zhou T, Zheng K, Sui B, Boccaccini AR, Sol J. In vitro evaluation of poly (vinyl alcohol)/collagen blended hydrogels for regulating human periodontal ligament fibroblasts and gingival fibroblasts. Int. J. Biol. Macromol. [Internet]. 2020 [Consultado el 12 de octubre de 2023];163: 1938–1946. doi: 10.1016/j.ijbiomac.2020.09.033

Chin SY, Poh YC, Kohler AC, Sia SK. An Additive Manufacturing Technique for the Facile and Rapid Fabrication of Hydrogel-based Micromachines with Magnetically Responsive Components. J Vis Exp. [Internet]. 2018 Jul 18 [Consultado el 12 de octubre de 2023];(137):56727. doi: 10.3791/56727

Isaac A, Jivan F, Xin S, Hardin J, Luan X, Pandya M, et al. Microporous Bio-orthogonally Annealed Particle Hydrogels for Tissue Engineering and Regenerative Medicine. ACS Biomater Sci Eng. [Internet]. 2019 Dec 9 [Consultado el 12 de octubre de 2023]; 5(12):6395-6404. doi: 10.1021/acsbiomaterials.9b01205

Zhu M, Wang Y, Ferracci G, Zheng J, Cho NJ, Lee BH. Gelatin methacryloyl and its hydrogels with an exceptional degree of controllability and batch-to-batch consistency. Sci Rep. [Internet]. 2019 May 3 [Consultado el 19 de noviembre de 2023];9(1):6863. doi: 10.1038/s41598-019-42186-x

Shen S, Zhang Y, Zhang S, Wang B, Shang L, Shao J, et al. 6-Bromoindirubin-3-oxime Promotes Osteogenic Differentiation of Periodontal Ligament Stem Cells and Facilitates Bone Regeneration in a Mouse Periodontitis Model. ACS Biomater Sci Eng. [Internet]. 2021 Jan 11 [Consultado el 19 de noviembre de 2023];7(1):232-241. doi: 10.1021/acsbiomaterials.0c01078

Gruber R. Osteoimmunology: Inflammatory osteolysis and regeneration of the alveolar bone. J Clin Periodontol. [Internet]. 2019 Jun [Consultado el 19 de noviembre de 2023];46 Suppl 21:52-69. doi: 10.1111/jcpe.13056

Mou J, Liu Z, Liu J, Lu J, Zhu W, Pei D. Hydrogel containing minocycline and zinc oxide-loaded serum albumin nanopartical for periodontitis application: preparation, characterization and evaluation. Drug Deliv. [Internet]. 2019 Dec [Consultado el 19 de noviembre de 2023];26(1):179-187.doi: 10.1080/10717544.2019.1571121

Chen N, Ren R, Wei X, Mukundan R, Li G, Xu X, et al. Thermoresponsive Hydrogel-Based Local Delivery of Simvastatin for the Treatment of Periodontitis. Mol Pharm. [Internet]. 2021 May 3 [Consultado el 19 de noviembre de 2023];18(5):1992-2003. doi: 10.1021/acs.molpharmaceut.0c01196

Mensah A, Rodgers AM, Larrañeta E, McMullan L, Tambuwala M, Callan JF, et al. Treatment of Periodontal Infections, the Possible Role of Hydrogels as Antibiotic Drug-Delivery Systems. Antibiotics (Basel). [Internet]. 2023 Jun 19 [Consultado el 19 de noviembre de 2023]; 12(6): 1073. doi: 10.3390/antibiotics12061073

Giannobile WV, Berglundh T, Al-Nawas B, Araujo M, Bartold PM, Bouchard P, et al. Biological factors involved in alveolar

bone regeneration: Consensus report of Working Group 1 of the 15th European Workshop on Periodontology on Bone Regeneration. J Clin Periodontol. 2019 Jun [Consultado el 19 de noviembre de 2023];46 Suppl 21:6-11. doi: 10.1111/jcpe.13130

Divband B, Aghazadeh M, Al-Qaim ZH, Samiei M, Hussein FH, Shaabani A, et al. Bioactive chitosan biguanidine-based injectable hydrogels as a novel BMP-2 and VEGF carrier for osteogenesis of dental pulp stem cells. Carbohydr Polym. [Internet]. 2021 Dec 1 [Consultado el 22 de diciembre de 2023];273:118589. doi: 10.1016/j.carbpol.2021.118589

Qu L, Dubey N, Ribeiro JS, Bordini EAF, Ferreira JA, Xu J, et al. Metformin-loaded nanospheres-laden photocrosslinkable gelatin hydrogel for bone tissue engineering. J Mech Behav Biomed Mater. [Internet]. 2021 Apr [Consultado el 22 de diciembre de 2023];116:104293. doi: 10.1016/j.jmbbm.2020.104293

Shi W, Guo S, Liu L, Liu Q, Huo F, Ding Y, et al. Small Extracellular Vesicles from Lipopolysaccharide-Preconditioned Dental Follicle Cells Promote Periodontal Regeneration in an Inflammatory Microenvironment. ACS Biomater Sci Eng. [Internet]. 2020 Oct 12 [Consultado el 22 de diciembre de 2023];6(10):5797-5810. doi: 10.1021/acsbiomaterials.0c00882

Liu S, Wang YN, Ma B, Shao J, Liu H, Ge S. Gingipain-Responsive Thermosensitive Hydrogel Loaded with SDF-1 Facilitates In Situ Periodontal Tissue Regeneration. ACS Appl Mater Interfaces. [Internet]. 2021 Aug 11 [Consultado el 22 de diciembre de 2023];13(31):36880-36893. doi: 10.1021/acsami.1c08855

Liu L, Guo S, Shi W, Liu Q, Huo F, Wu Y, et al. Bone Marrow Mesenchymal Stem Cell-Derived Small Extracellular Vesicles Promote Periodontal Regeneration. Tissue Eng Part A. [Internet]. 2021 Jul [Consultado el 22 de diciembre de 2023]; 27(13-14): 962-976. doi: 10.1089/ten.TEA.2020.0141

Cui P, Pan P, Qin L, Wang X, Chen X, Deng Y, et al. Nanoengi neered hydrogels as 3D biomimetic extracellular matrix with injectable and sustained delivery capability for cartilage regeneration. Bioact Mater. [Internet]. 2022 May 4 [Consultado el 22 de diciembre de 2023];19:487-498. doi: 10.1016/j.bioactmat.2022.03.032

Farazin A, Aghadavoudi F, Motiffard M, Saber-Samandari S, Khandan A. Nanostructure, Molecular Dynamics Simulation and Mechanical Performance of PCL Membranes Reinforced with Antibacterial Nanoparticles. J. Appl. Comput. Mech. [Internet]. 2021 [Consultado el 22 de diciembre de 2023];7:1907–1915. doi: 10.22055/jacm.2020.32902.2097

Xu Y, Zhao S, Weng Z, Zhang W, Wan X, Cui T, et al. Jelly-Inspired Injectable Guided Tissue Regeneration Strategy with Shape Auto-Matched and Dual-Light-Defined Antibacterial/Osteogenic Pattern Switch Properties. ACS Appl Mater Interfaces. [Internet]. 2020 Dec 9 [Consultado el 22 de diciembre de 2023];12(49):54497-54506. doi: 10.1021/acsami.0c18070

Liu Y, Zhu Z, Pei X, Zhang X, Cheng X, Hu S, et al. ZIF-8-Modified Multifunctional Bone-Adhesive Hydrogels Promoting Angiogenesis and Osteogenesis for Bone Regeneration. ACS Appl Mater Interfaces. [Internet]. 2020 Aug 19 [Consultado el 22 de diciembre de 2023]; 12(33): 36978-36995. doi: 10.1021/acsami.0c12090

Mustfa SA, Maurizi E, McGrath J, Chiappini C. Nanomedicine Approaches to Negotiate Local Biobarriers for Topical Drug Delivery. Adv. Ther. [Internet]. 2020 [Consultado el 5 de agosto de 2023];4:2000160. doi: https://onlinelibrary.wiley.com/doi/10.1002/adtp.202000160

Li N, Xie L, Wu Y, Wu Y, Liu Y, Gao Y, et al. Dexamethasone-loaded zeolitic imidazolate frameworks nanocomposite hydrogel with antibacterial and anti-inflammatory effects for periodontitis treatment. Mater Today Bio. [Internet]. 2022 Jul 20 [Consultado el 22 de diciembre de 2023];16:100360. doi: 10.1016/j.mtbio.2022.100360

Ran J, Zeng H, Cai J, Jiang P, Yan P, Zheng L, et al. Rational design of a stable, effective, and sustained dexamethasone delivery platform on a titanium implant: an innovative application of metal organic frameworks in bone implants. Chem. Eng. J. [Internet]. 2018 [Consultado el 22 de diciembre de 2023];333:20–33. doi: https://www.scincedirect.com/science/article/pii/S1385894717316443

Cui P, Pan P, Qin L, Wang X, Chen X, Deng Y, Zhang X. Nanoengineered hydrogels as 3D biomimetic extracellular matrix with injectable and sustained delivery capability for cartilage regeneration. Bioact Mater. [Internet]. 2022 May 4 [Consultado el 22 de diciembre de 2023];19:487-498. doi: 10.1016/j.bioactmat.2022.03.032

Zhang S, Ou Q, Xin P, Yuan Q, Wang Y, Wu J. Hybrid hydrogels incorporated with polydopamine/puerarin nanoparticles to improve wound healing. [Internet]. 2019 Octuber 1 [Consultado el 22 de diciembre de 2023];7(10):4230-4236. doi: 10.1039/C9BM00991D

Mou J, Liu Z, Liu J, Lu J, Zhu W, Pei D. Hydrogel containing minocycline and zinc oxide-loaded serum albumin nanopartical for periodontitis application: preparation, characterization and evaluation. Drug Deliv. [Internet]. 2019 Dec [Consultado el 22 de diciembre de 2023];26(1):179-187. doi: 10.1080/10717544.2019.1571121

Alipour M, Ashrafhelan J, Salehi R, Aghazadeh Z, Rezabakhsh A, Hassanzadeh A, et al. In vivo evaluation of biocompatibility and immune modulation potential of poly(caprolactone)-poly(ethylene glycol)-poly(caprolactone)-gelatin hydrogels enriched with nano-hydroxyapatite in the model of mouse. J Biomater Appl. [Internet]. 2021 May [Consultado el 22 de diciembre de 2023];35(10):1253-1263. doi: 10.1177/0885328221998525

Madl CM, Heilshorn SC. Engineering Hydrogel Microenvironments to Recapitulate the Stem Cell Niche. Annu Rev Biomed Eng. [Internet]. 2018 Jun 4 [Consultado el 22 de diciembre de 2023];20:21-47. doi: 10.1146/annurev-bioeng-062117-120954

Atia GAN, Shalaby HK, Ali NG, Morsy SM, Ghobashy MM, Attia HAN, et al. New Challenges and Prospective Applications of Three-Dimensional Bioactive Polymeric Hydrogels in Oral and Craniofacial Tissue Engineering: A Narrative Review. Pharmaceuticals (Basel). [Internet]. 2023 May 5 [Consultado el 22 de diciembre de 2023];16(5):702. doi: 10.3390/ph16050702

Sun H, Xu J, Wang Y, Shen S, Xu X, Zhang L, Jiang Q. Bone microenvironment regulative hydrogels with ROS scavenging and prolonged oxygen-generating for enhancing bone repair. Bioact Mater. [Internet]. 2023 Jan 9 [Consultado el 22 de diciembre de 2023];24:477-496. doi: 10.1016/j.bioactmat.2022.12.021

Champeau M, Heinze DA, Viana TN; de Souza ER, Chinellato AC. Titotto S. 4D Printing of Hydrogels: A Review. Adv. Funct. Mater. [Internet]. 2020 [Consultado el 22 de diciembre de 2023];30:1910606. doi: https://doi.org/10.1002/adfm.201910606

Zhang Z, Bi F, Guo W. Research Advances on Hydrogel-Based Materials for Tissue Regeneration and Remineralization in Tooth. Gels. [Internet]. 2023 Mar 20 [Consultado el 22 de diciembre de 2023];9(3):245. doi: 10.3390/gels9030245

Liu Y, Li T, Sun M, Cheng Z, Jia W, Jiao K, Wang S, Jiang K, Yang Y, Dai Z, Liu L, Liu G, Luo Y. ZIF-8 modifed multifunctional injectable photopolymerizable GelMA hydrogel for the treatment of periodontitis. Acta Biomater. [Internet]. 2022 Jul 1 [Consultado el 22 de diciembre de 2023];146:37-48. doi: 10.1016/j.actbio.2022.03.046

Lin J, He Z, Liu F, Feng J, Huang C, Sun X, Deng H. Hybrid Hydrogels for Synergistic Periodontal Antibacterial Treatment with Sustained Drug Release and NIR-Responsive Photothermal Effect. Int J Nanomedicine. [Internet]. 2020 Jul 29 [Consultado el 22 de diciembre de 2023]; 15:5377-5387. doi: 10.2147/IJN.S248538

Published

2024-04-05

How to Cite

1.
Falcon-Guerrero BE, Falcón-Pasapera GS. Theoretical considerations of hydrogel therapy for periodontal tissue regeneration. Rev Peru Cienc Salud [Internet]. 2024Apr.5 [cited 2024Nov.22];6(2). Available from: http://revistas.udh.edu.pe/index.php/RPCS/article/view/472