Caracterización de la evolución del síndrome post-COVID-19 en Cochabamba, Bolivia, 2020-2021

Rommer Alex Ortega Martinez; Carla Alejandra Arellano Valdivia; Diana Isabel  Ríos Tejada; Carlos Enrique Román Calvimontes

doi:10.37711/rpcs.2023.5.2.415

Authors

Rommer Alex Ortega Martinez Universidad del Valle https://orcid.org/0000-0001-8702-3405
Carla Alejandra Arellano Valdivia Universidad Privada del Valle, Cochabamba, Bolivia. https://orcid.org/0000-0003-4332-3224
Diana Isabel Ríos Tejada Universidad Privada del Valle, Cochabamba, Bolivia https://orcid.org/0009-0005-6952-144X
Carlos Enrique Román Calvimontes Universidad Mayor de San Simon, Cochabamba, Bolivia. https://orcid.org/0009-0008-9949-1052

DOI:

https://doi.org/10.37711/rpcs.2023.5.2.415

Keywords:

long-term COVID-19, post-COVID-19 conditions, clinical course, post-acute COVID-19 syndrome, post-acute sequelae of SARS-CoV-2 infection

Abstract

Objectives. To characterize the evolution of post-COVID-19 syndrome in Cochabamba-Bolivia, 2020-2021. Methods. Prospective, observational and analytical study. The sample consisted of 62 patients surveyed with COVID-19. Symptom severity and persistence were investigated. Fisher's exact test, calculation of the n coefficient, Kruskal-Wallis test, Mann-Whitney U, in addition to binary logistic regression were applied. Results. The mean age was 34.2 ± 11.6 years; dyspnea was present in 45% and cough with 42%; precordial pain
with 30%; asthenia and myalgias with 29%; anxiety and depression with 47%,
memory and concentration alteration with 24%; predominant risk factor obesity in 11%. Symptom evolution was for more than 10 days in 48%; hospitalization was between 1 to 7 days in 23 % of cases; a decrease in work performance was observed
in 34%, in quality of life in 23% and economic affectation in 58%. Symptom
persistence was present in 50%, correlated with hospitalization, decreased quality of life and baseline disease (p < 0.05); in addition, an OR: 4.87, 95% CI (1.54-17.2) was obtained for moderate symptoms and an OR: 4.42, 95% CI (1.28-17.6) for hospitalization in symptom persistence. Conclusions. The presence of young patients, mild and moderate symptoms and varied symptomatology stands out. The persistence of symptoms was related to hospitalization and moderate
symptoms; we can suggest post-acute COVID-19 syndrome and chronic
COVID-19 syndrome (< and > 12 weeks), as tentative defnitions, although more studies are still needed

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References

Yong SJ Long COVID or post-COVID-19 syndrome: putative pathophysiology, risk factors, and treatments. Infectious Diseases [Internet]. 2021 [Consultado 2023 Ene 15]; 53(10): 737-754. https://doi.org/10.1080/23744235.2021.1924397

Khan M, Adil SF, Alkhathlan HZ COVID-19: A Global Challenge with Old History, Epidemiology and Progress So Far. Molecules [Internet]. 2021 [Consultado 2022 Jun 10]; 26(39): 1-25. https://dx.doi.org/10.3390/molecules26010039

Alwan NA, Johnson L. Defning long COVID: Going back to the start. Med 2 [Internet]. 2021 May 14 [Consultado 2021 Nov 19]; 2(5): 456-504. https://doi.org/10.1016/j.medj.2021.03.003

Raavendran AV, Jayadevan R, Sashidharan S. Long COVID: An overview. Diabetes & Metabolic Syndrome: Clinical Research & Reviews [Internet]. 2021 [Consultado 2022 Ene 10]; 15(3): 869-875. https://doi.org/10.1016/j.dsx.2021.04.007

Tirelli U, Taibi R, Chirumbolo S. Post COVID syndrome: a new challenge for medicine. European Review for Medical and Pharmacological Sciences. 2021; 25: 4422-4425

Fernández de las Peñas C. Long COVID: current defnition Infection [Internet]. 2022 [Consultado 2023 Feb 20]; 50: 285-286. https://doi.org/10.1007/s15010-021-01696-5

Akbarialiabad H, Hossein Taghrir M, Ghahramani N. Long COVID, a comprehensive systematic scoping review. Infection [Internet]. 2021 Jul 28 [Consultado 2022

Ago 21]; 49: 1-28. https://doi.org/10.1007/s15010-021-01666-x

Lledo GM, Sellares J, Brotons C. Post-acute COVID-19 syndrome: a new tsunami requiring a universal case defnition. Clinical Microbiology and Infection [Internet]. 2021 [Consultado 2022 Oct 17]; 28(3): 315-318. https://doi.org/10.1016/j.cmi.2021.11.015

Mumoli N, Conte G, Evangelista I. Post-COVID or longCOVID: Two different conditions or the same? Journal of Infection and Public Health [Internet]. 2021 [Consultado 2022 Oct 17]; 14(10): 1349-1350. https://doi.org/10.1016/j.jiph.2021.08.019

Nichelem M. Post covid syndrome review. BMJ Global Health [Internet]. 2020 [Consultado 2021 Nov 20]; 6. doi: 10.1136/bmjgh-2021-005427

Wostyn P. COVID-19 and chronic fatigue syndrome: Is the worst yet to come? Medical Hipotheses. 2021; 146: 1-6.

Raveendran AV Long COVID-19: Challenges in the diagnosis and proposed diagnostic criteria. Diabetes & Metabolic Syndrome: Clinical Research & Reviews [Internet]. 2021 Nov [Consultado 2022 Mar 10]; 15(1): 145-146. https://doi.org/10.1016/j.dsx.2020.12.025

Nalbandian A, Sehgal K, Gupta A. Post-acute COVID-19 syndrome. Nature Medicine [Internet]. 2021 [Consultado 2022 mar 10]; 27: 601-615. https://doi.org/10.1038/

s41591-021-01283-z

Mannan Baig A. Chronic COVID Syndrome: Need for an appropriate medical terminology for Long-COVID and COVID Long-haulers. J Med Virol. [Internet]. 2021 May [Consultado 2022 Mar 10]; 93(5): 2555-25. doi:10.1002/jmv.26624

Oronsky B, Larson C, Hammond TC. A Review of Persistent Post COVID Syndrome (PPCS). Clinical Reviews in Allergy & Immunology [Internet]. 2021 Feb [Consultado 2022 Mar 10]; 64: 66-74. https://doi.org/10.1007/s12016-021-08848-3

Hoffer EP. Long COVID: Does It Exist? What Is It? We Can We Do For Sufferers? The America Journal of Medicine [Internet]. 2021 Nov [Consultado 2022 Jun 16]; 134(11): 1310-1311. https://doi.org/10.1016/j.amjmed.2021.05.023

Vink M, Vink-Niese A. Could Cognitive Behavioural Therapy Be an Effective Treatment for Long COVID and Post COVID-19 Fatigue Syndrome? Lessons from the Qure Study for Q-Fever Fatigue Syndrome. Healthcare [Internet]. 2020 [Consultado 2021 Feb 20]; 8(552): 1-17.

doi: 10.3390/healthcare8040552

Organización Mundial de la Salud (OMS). Manejo clínico de la COVID-19, Orientaciones evolutivas [Internet]. 2021 [Consultado 2022 Jul 10]. https://apps.who.int/iris/handle/10665/340629

Pavli A, Theodoridou M, Maltezou H.C. Post-COVID syndrome: Incidence, clinical spectrum, and challenges for primary healthcare professionals. Archives of Medical Research [Internet]. 2021 May [Consultado 2022 Mar 10]; 4(49): 1-8. https:// doi.org/ 10.1016/j.arcmed.2021.03.010

Desgranges F, Tadini E, Munting A. Post COVID 19 Syndrome in Outpatients: a Cohort Study. J Gen Intern Med. 2022; 37(8): 1943-1952.

Montani D, Savale L, Noel N. Post-acute COVID-19 syndrome. Eur Respir Rev. [Internet]. 2022[Consultado 2023 Feb 15]; 31(163). doi: 10.1183/16000617.0185-2021

Desai AD, Lavelle M, Boursiquot BC. Long-term complications of COVID-19. Am J Physiol Cell Physiol. [Internet]. 2022 [Consultado 2023 Feb 15]; 322(1): 1-11.

doi:10.1152/ajpcell.00375.202123. Post-acute COVID-19 syndrome (PCS) and health-related quality of life (HRQoL)—A systematic review and meta-analysis. J Med Virol. [Internet]. 2022 [Consultado 2023 Feb 15]; 94(1): 253-262. doi: 10.1002/jmv.27309

NICE Guideline, Scottish Intercollegiate Guidelines Network (SIGN). COVID-19 rapid guideline: managing the long-term effects of COVID-19 [Internet]. 2020 [Consultado 2022 Dic 20]. https://pubmed.ncbi.nlm.nih.gov/33555768/

Greenhalgh T, Knight M, A’Court C. Management of post-acute covid-19 in primary care. BMY [Internet]. 2020 Ago [Consultado 2021 Feb 10] 11; 370. doi: 10.1136/bmj.m3026